Endocrine Abstracts

Introduction: Primary aldosteronism (PA) is a common cause of secondary hypertension that can lead to renal sequelae. Treatment of hyperaldosteronism leads to reductions in albuminuria and glomerular hyperfiltration. We aimed to evaluate the effect of treatment on albuminuria and temporal changes in renal function after treatment with both surgery and medications.Methods: We prospectively recruited patients with PA over three years. Spot urine samples fo...

Introduction: Although the Endocrine Society guidelines recommend using aldosterone: renin ratio (ARR) to screen patients for primary aldosteronism (PA), whether to include a cut-off for aldosterone levels remains controversial. In Singapore, most centres require both an ARR >550 (ng/dl)/(ng/ml per h) and aldosterone ≥15 ng/dl. However, it has been shown that patients with PA may have aldosterone levels<15 ng/dl, and also respond well to mineralocorticoid antagon...

Background: Patients with an elevated aldosterone renin ratio (ARR) should proceed for a confirmatory test to diagnose primary aldosteronism (PA) before undergoing further investigations such as CT imaging and adrenal venous sampling. The recent 2016 clinical guidelines have included a new recommendation: that in the setting of spontaneous hypokalaemia, undetectable plasma renin, and plasma aldosterone concentration (PAC) >20 ng/dl, patients may not require further confirm...

BackgroundPrimary aldosteronism (PA) affects 5-20% of all patients with hypertension, and is likely the most common treatable cause of hypertension. Patients with PA have higher risk of cardiovascular disease, atrial fibrillation and stroke. We aimed to estimate the prevalence of PA in patients with recent stroke.MethodsWe prospectively recruited 300 patients who were admitted to the acute stroke unit of a si...

Introduction: Patients with unilateral primary aldosteronism (PA) can be cured with adrenalectomy, and adrenal vein sampling (AVS) remains the gold-standard test. However, AVS is invasive, technically-challenging and criteria for determining lateralization differ between centres. 11C-Metomidate PET/CT (MTO) imaging offers a promising non-invasive alternative for identifying unilateral PA.Methods: All patients with confirmed primary aldosteronism who were...